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Kumudha Balakrishnan Selected Research

forodesine

8/2013Preclinical and clinical evaluation of forodesine in pediatric and adult B-cell acute lymphoblastic leukemia.
8/2010Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells.
8/2010Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia.
10/2006Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells.

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Kumudha Balakrishnan Research Topics

Disease

21B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
10/2018 - 09/2005
12Neoplasms (Cancer)
01/2021 - 10/2006
4Leukemia
10/2018 - 09/2005
3Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
01/2021 - 11/2009
3Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
06/2014 - 09/2007
2Lymphopenia (Lymphocytopenia)
08/2013 - 12/2007
2Purine Nucleoside Phosphorylase Deficiency
08/2013 - 10/2006
2Hematologic Neoplasms (Hematological Malignancy)
04/2012 - 12/2007
1Ataxia Telangiectasia (Louis Bar Syndrome)
01/2021
1B-Cell Lymphoma (Lymphoma, B Cell)
01/2021
1Triple Negative Breast Neoplasms
10/2018
1Breast Neoplasms (Breast Cancer)
10/2018
1Lymphoma (Lymphomas)
01/2016
1Diarrhea
06/2014
1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
08/2013
1T-Cell Leukemia (Leukemia, T Cell)
08/2013
1Lymphocytosis
02/2012
1Disease Progression
02/2012
1T-Lymphocytopenia
10/2006
1Multiple Myeloma
06/2005

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
08/2015 - 09/2005
4Purine-Nucleoside PhosphorylaseIBA
08/2013 - 10/2006
4forodesineIBA
08/2013 - 10/2006
3Reactive Oxygen Species (Oxygen Radicals)IBA
10/2018 - 12/2011
3ibrutinibIBA
07/2017 - 02/2012
3DNA (Deoxyribonucleic Acid)IBA
06/2017 - 11/2009
3deoxyguanosine triphosphate (dGTP)IBA
08/2013 - 10/2006
3RNA (Ribonucleic Acid)IBA
11/2009 - 06/2005
2Phosphotransferases (Kinase)IBA
01/2021 - 02/2012
2Protein Kinases (Protein Kinase)IBA
01/2021 - 04/2012
2Agammaglobulinaemia Tyrosine KinaseIBA
07/2017 - 02/2012
2Cyclophosphamide (Cytoxan)FDA LinkGeneric
06/2014 - 09/2007
2Clofarabine (Clolar)FDA Link
06/2014 - 09/2007
2NucleosidesIBA
06/2014 - 09/2005
2fludarabineIBA
08/2010 - 08/2010
2triphosphoric acid (triphosphate)IBA
10/2006 - 06/2005
1Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone (FCCP)IBA
01/2021
1Carbonyl Cyanide m-Chlorophenyl Hydrazone (CCCP)IBA
01/2021
1Amino AcidsFDA Link
10/2018
1Chlorambucil (Leukeran)FDA Link
10/2018
1Pharmaceutical PreparationsIBA
10/2018
1EstersIBA
10/2018
1Melphalan (Alkeran)FDA LinkGeneric
10/2018
1acalabrutinibIBA
07/2017
1hydroxide ionIBA
06/2017
1Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
06/2017
1quinone methideIBA
06/2017
1Alkylating AgentsIBA
03/2017
1Bendamustine HydrochlorideFDA Link
03/2017
1idelalisibIBA
03/2017
1Apoptosis Regulatory ProteinsIBA
01/2016
1Caspase 3 (Caspase-3)IBA
01/2016
1venetoclaxIBA
08/2015
1NitrogenIBA
06/2014
1Transaminases (Aminotransferases)IBA
06/2014
1Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
04/2014
1navitoclaxIBA
10/2013
1apogossypoloneIBA
05/2013
1ProdrugsIBA
12/2011
1Mechlorethamine (Nitrogen Mustard)FDA Link
12/2011
18-chloroadenosineIBA
11/2009
1B-Cell Antigen Receptors (B Cell Antigen Receptors)IBA
07/2009
1Syk KinaseIBA
07/2009
1GossypolIBA
09/2008
1Deoxycytidine KinaseIBA
10/2006
1Adenosine Triphosphate (ATP)IBA
06/2005
1Messenger RNA (mRNA)IBA
06/2005
1Adenosine (Adenocard)FDA LinkGeneric
06/2005

Therapy/Procedure

4Therapeutics
03/2017 - 08/2010
2Drug Therapy (Chemotherapy)
06/2014 - 12/2011